What Exactly Is a DNA Test? What It Does — and Doesn’t — Tell You About Your Health

If you’ve ever wondered whether a DNA test can help you understand your health, your gut, your hormones or your energy levels, you’re not alone. Genetic testing has become incredibly popular — but also incredibly misunderstood. Many people either overestimate what a DNA test can reveal, or dismiss it because they assume it screens for diseases it actually doesn’t test for.

So let’s clear the confusion.

As a naturopath who specialises in gut health and genetics, I use DNA testing every day to help clients personalise their diet, lifestyle and supplementation. And the first thing I always explain is this:

A functional DNA test is NOT a disease-diagnosis tool and It is a powerful way to understand how your body is wired, so you can support it properly.

Here’s exactly what a DNA test does and doesn’t look for.

What a DNA Test Does Test For?

Most functional or wellness-focused DNA panels (like Smart DNA or similar practitioner tests) analyse your genetics in areas that affect everyday health, resilience and metabolism — not diseases.

1. How You Process Nutrients:

A DNA test can reveal how efficiently your body makes, converts or uses key nutrients such as:

  • Folate and methylation nutrients (MTHFR and related pathways)

  • Vitamin A conversion (BCMO1)

  • Antioxidants like glutathione (GSTs, GPX)

  • Omega-3 and omega-6 metabolism

  • Vitamin D receptor efficiency

A DNA test can reveal how efficiently your body makes, converts or uses key nutrients such as:

2. How Well You Detoxify

These liver enzymes determine which pathway oestrogen goes down.

  • Glutathione production

  • Phase I & II detox enzymes

  • Your ability to neutralise pollutants, toxins, oestrogens and chemicals

  • How efficiently your body clears oxidative stress

This is especially useful for clients with sensitivities, fatigue, hormonal issues or slow detox symptoms.


3. Inflammation & Cellular Defence

Genetic variations can tell us:

  • Whether your body tends towards higher inflammatory signalling

  • How effective your antioxidant defence systems are

  • How effective your antioxidant defence systems are

4. Gut Health Influencers

A DNA test can’t measure your microbiome — but it can reveal genetic factors that shape your gut environment. For example:

  • Secretor status (FUT2) — affects microbiome composition, immunity and digestive health

  • Digestive enzyme genes — lactose tolerance, sucrase–isomaltase, amylase levels

  • TNFSF15 — associated with immune activation in the gut

These genes help explain why some people react strongly to foods, infections or stress.

5. Hormones, Mood & Stress Response

A DNA test can assess:

  • How your body breaks down oestrogen

  • Stress hormones like adrenaline and dopamine (COMT, MAOA)

  • Serotonin-related pathways

  • Cortisol sensitivity

This is especially useful for perimenopause, anxiety, PMS and energy concerns.

6. Metabolism, Weight & Exercise Response

Metabolism, Weight & Exercise Response:

  • Fat and carbohydrate metabolism

  • Appetite regulation

  • Tendencies toward weight gain or insulin resistance

  • Injury risk, muscle fibre type or exercise recovery

These are not destiny — but they help explain what works (and doesn’t) for your body.

What a DNA Test Does NOT Test For

This is the part many people get wrong, so let’s say it clearly:

Wellness DNA tests DO NOT screen for:

  • 1

    Inherited diseases (like BRCA breast cancer genes)

  • 2

    Genetic disorders

  • 3

    Diagnosable medical conditions

  • 4

    Alzheimer’s risk genes

  • 5

    Cardiovascular disease mutations

  • 6

    Anything used for medical diagnosis

Those types of tests fall under clinical genetic testing and are ordered by medical specialists with specific counselling and consent requirements.

A functional DNA test is not designed to tell you what diseases you have or will get.

Instead, it highlights functional tendencies — the way your body prefers to work — so we can make smarter choices around diet, lifestyle, and targeted support.

So… Why Do a DNA Test at All?

Because understanding your genetic tendencies allows you to work with your biology, not against it.

A DNA test helps answer questions like:

  • 1

    Inherited diseases (like BRCA breast cancer genes)

  • 2

    Genetic disorders

  • 3

    Diagnosable medical conditions

  • 4

    Alzheimer’s risk genes

  • 5

    Cardiovascular disease mutations

  • 6

    Anything used for medical diagnosis

When clients see their genetic report, the most common reaction is:

“This explains so much.”

It’s not about diagnosis — it’s about clarity.

Final Thoughts

A DNA test won’t tell you what illnesses you have.

It won’t diagnose disease.

It won’t predict your medical future.

If you’re dealing with fatigue, gut issues, hormone imbalances or “mystery symptoms” that no one can solve, a DNA test can provide the missing piece that ties everything together.

But it will give you a personalised roadmap for how to support your body based on your unique biology.